منابع مشابه
Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules.
The 140-residue protein alpha-synuclein (aS) has been implicated in the molecular chain of events leading to Parkinson's disease, which relates to the hierarchical aggregation of aS into soluble oligomers and insoluble fibrils. A number of small organic molecules have been reported to inhibit aS aggregation. Here, the interactions of chlorazole black E, Congo red, lacmoid, PcTS-Cu (2+), and ros...
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IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking. A high affinity IL-17A peptide antagonist (HAP) of 15 residues was identified through phage-display screening followed by saturation mutagenesis optimization and amin...
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The process of epithelial-mesenchymal transition (EMT) which is required for cancer cell invasion is regulated by a family of E-box-binding transcription repressors, which include Snail (SNAIL1) and Slug (SNAI2). Snail appears to repress the expression of the EMT marker E-cadherin by epigenetic mechanisms dependent on the interaction of its N-terminal SNAG domain with chromatin-modifying protei...
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Scorpion toxins are important pharmacological tools for probing the physiological roles of ion channels which are involved in many physiological processes and as such have significant therapeutic potential. The discovery of new scorpion toxins with different specificities and affinities is needed to further characterize the physiology of ion channels. In this regard, a new short polypeptide cal...
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3T3 cells are shown to reduce SV40-3T3 cell population growth in a denisty-dependent manner in co-cultures of 3T3 and SV40-3T3 cells. The development of this inhibitory activity roughly parallels the development of density-dependent inhibition of growth in homogeneous 3T3 control cultures. The extent of reduction of SV40-3T3 growth can be manipulated by pretreatment of 3T3 cells with a high ser...
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ژورنال
عنوان ژورنال: Science
سال: 2009
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.325_657b